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Survival of Implanted Fetal Dopamine Cells & Neuro Improvement 12 to 46 Months after Transpl for Parkinson's NEJM 327:1549-1555, 15891992., Freed,C.R.,et al, 1992 See this aricle in Pubmed Article Abstract All patients reported improvement according to the Activities of Daily Living Scale when in the on state 3 to 12 months after surgery(P<0.01). Neurologic examination according to the Unified Disease Rating Scale showed that five of the seven patients improved when in the on state six months after surgery.The mean group Hoehn-Yahr score improved from 3.71 to 2.50(P<0.01).Computer and videotape testing in the home supported these findings.Fluctuations in the patients'clinical state were moderated,and periods of dyskinesia and off episodes were shorter and less severe than before implantation.Drug doses were reduced by an average of 39 percent(P< 0.01;maximum,58 percent).The results of clinical evaluation and fluorodopa positron-emission tomography in one patient were compatible with transplant survival for as long as 46 months.Both immunosuppressed and nonimmunosuppressed patients improved.Fetal-tissue implants appear to offer long-term clinical benefit to some patients with advanced Parkinson' s disease.

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(click to filter results - removes previous filter) activities of daily living activities of daily living scale brain transplantation CAT scan,emission disability rating scale,neurological fetal tissue Hoehn-Yahr scale Parkinson disease Parkinson disease,surgical treatment of Parkinson disease,treatment of substantia nigra tissue treatment of neurologic disorder

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